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Topography-guided LASIK Surgery

January 15, 2020


Stanford University is holding a study on the results of topography-guided LASIK surgery for myopia (nearsightedness) and myopic astigmatism. Researchers will compare the preoperative and postoperative anterior segment optical coherence tomography epithelial thickness maps after surgery at one month, three months, six months, and twelve months. They hope comparing these maps will show how UDVA and CDVA improve. 


Study Information

There is an estimated enrollment of 35 participants. Researchers will monitor:

  • Changes in corrected visual acuity
  • Uncorrected distance visual acuity
  • Quality of Vision via questionnaire
  • Percentage of eyes within +/-0.25, 0.50 and 1.00 diopter of the intended correction
  • Contrast visual acuity 
  • Residual astigmatism levels after surgery
  • Change in spherical equivalent over time.


Inclusion Criteria


All sexes, ages 18 to 59 years old, are allowed to participate. To be included in the study, participants must have:

  • Healthy eyes
  • Nearsightedness between -0.50 diopters and -8.00 diopters.
  • Up to 3.00 diopters of astigmatism.
  • A spherical equivalent of up to -9.00 diopters


Exclusion Criteria


Those now allowed to participate are subjects who have:

  • Excessively thin corneas.
  • Topographic evidence of keratoconus.
  • Ectatic eye disorders.
  • Autoimmune diseases.
  • Who are pregnant or nursing.
  • More than 3.00 diopters of astigmatism



Those interested may participate in this study at Byers Eye Institute at Stanford in Palo Alto, California, 94303. Feel free to contact Linda Schwartz at 650 498-7020 with any questions or concerns.



This clinical trial is sponsored by Stanford University. The Principal Investigator is Edward E. Manche.

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